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2 edition of Regulation of the ERK MAP kinase cascade by the Eph family of receptor tyrosine kinases. found in the catalog.

Regulation of the ERK MAP kinase cascade by the Eph family of receptor tyrosine kinases.

Sabine Elowe

Regulation of the ERK MAP kinase cascade by the Eph family of receptor tyrosine kinases.

by Sabine Elowe

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Published .
Written in English


About the Edition

Members of the Eph family of proteins were identified as the first family of receptor tyrosine kinases (RTKs) specifically able to attenuate of ERK signalling in cells of varying origin. This downregulation occurs at the level of Ras, and is dependent on the presence of functional p120Ras GTPase activating protein (GAP), a negative regulator of the Ras-ERK cascade, which associates with the Eph receptors. Furthermore, the ability of Eph receptors to downregulate Ras-ERK signalling correlates with neurite retraction in cultured neuronal cell systems, and the inhibition of Eph receptor-induced decrease in Ras-GTP levels severely impairs growth cone collapse. Moreover, we have selectively engineered Eph receptors that can stabilize or activate ERK through rational introduction of Grb2-binding motifs into the receptor EphB2. These experiments revealed the presence of secondary RasGAP docking motifs in EphB2; and show that through abrogation of RasGAP association, and concomitant introduction of Grb2 binding sites, Eph signalling can be effectively switched from inhibiting to stimulating the ERK cascade. In certain cell types however, Eph receptors function as classical RTKs, with ligand stimulation leading to recruitment of ShcA and Grb2, and subsequent ERK activation. These studies of Eph receptors reveal a unique and novel signalling mode for this family of RTKs, with significant implications for understanding of the physiological roles of these proteins.

The Physical Object
Pagination195 leaves.
Number of Pages195
ID Numbers
Open LibraryOL19475645M
ISBN 100494028327

  Receptor tyrosine kinases are a subclass of cell-surface growth-factor receptors with an intrinsic, ligand-controlled tyrosine-kinase activity. They regulate diverse functions in normal cells and Cited by: Summary. The MAP kinases ERK1 and ERK2 represent a subfamily of the protein kinases with a significant role in hormonal signal transduction. They are ubiquitous, growth factor-stimulated protein kinases that phosphorylate and thereby modulate the properties of many proteins that have key regulatory : M. H. Cobb, J. E. Hepler, E. Zhen, D. Ebert, M. Cheng, A. Dang, D. Robbins.

Overview. Receptor tyrosine kinases (RTK)s are the high affinity cell surface receptors for many polypeptide growth factors, cytokines and the ninety unique tyrosine kinase genes idenitified in the human genome, 58 encode receptor tyrosine kinase proteins. Receptor tyrosine kinases have been shown to be not only key regulators of normal cellular processes but also to have a. Kinase Classification: Group CMGC: Family MAPK. The MAPKs (Mitogen Activated Protein Kinase) are the final kinases of the MAPK cascade, which relay signals from the cell surface for growth, stress and other best-known MAPKs include Erk, which relays growth signals from the ras/raf pathway and receptor kinases, and the JNK and p38 subfamilies, which relay various stress signals.

-Receptor tyrosine kinases (RTKs) recognize them-Binding of the ligand initiates a signal-transduction cascase including Ras (a monomeric G-protein)-Ras passes the signal to downstream effectorsChanges in the gene expression to move into S phase. Receptor Tyrosine Kinases (RTKs) are widely expressed transmembrane proteins that act as receptors for growth factors, neurotrophic factors, and other extracellular signaling molecules. Upon ligand binding, they undergo tyrosine phosphorylation at specific residues in the cytoplasmic tail.


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Regulation of the ERK MAP kinase cascade by the Eph family of receptor tyrosine kinases by Sabine Elowe Download PDF EPUB FB2

Eph receptors (Ephs, after erythropoietin-producing human hepatocellular receptors) are a group of receptors that are activated in response to binding with Eph receptor-interacting proteins (Ephrins).Ephs form the largest known subfamily of receptor tyrosine kinases (RTKs). Both Eph receptors and their corresponding ephrin ligands are membrane-bound proteins that require direct cell-cell InterPro: IPR ERK1/2 MAP kinases: structure, function, and regulation.

Roskoski R Jr(1). Author information: (1)Blue Ridge Institute for Medical Research, Brevard Road, SuiteHorse Shoe, NCUSA.

[email protected] ERK1 and ERK2 are related protein-serine/threonine kinases that participate in the Ras-Raf-MEK-ERK signal transduction by: Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and the 90 unique tyrosine kinase genes identified in the human genome, 58 encode receptor tyrosine kinase proteins.

Receptor tyrosine kinases have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the BRENDA: BRENDA entry.

The Eph transmembrane tyrosine kinases constitute the largest known family of receptor-like kinases, with many members displaying specific patterns of expression in the developing and adult Cited by:   Activation of the EphA2 tyrosine kinase stimulates the MAP/ERK kinase signaling cascade.

Pratt RL(1), Kinch MS. Author information: (1)Department of Basic Medical Sciences, Purdue University Cancer Center, West Lafayette, Indiana, INby: ERK1 and ERK2 are related protein-serine/threonine kinases that participate in the Ras-Raf-MEK-ERK signal transduction cascade.

This cascade participates in the regulation of a large variety of processes including cell adhesion, cell cycle progression, cell migration, cell survival, differentiation, metabolism, proliferation, and by: The linear sequence of Raf → MEK → ERK constitutes the ERK cascade.

Although the ERK cascade is activated through growth factor-regulated receptor protein tyrosine kinases, they are also modulated through G protein-coupled receptors (GPCRs).

All four G protein subfamilies (G q/11, G i/o, G s and G 12/13) influence the activation state of Cited by: The mammalian MAP kinases consist of cytoplasmic protein-serine/threonine kinases that participate in the transduction of signals from the surface to the interior of the cell.

This group includes the extracellular signal-regulated kinase (ERK) family, the p38 kinase family, and the c-Jun N-terminal kinase family (JNK. Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and the 90 unique tyrosine kinase genes identified in the human genome, 58 encode receptor tyrosine kinase proteins.

Receptor tyrosine kinases have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the. Structure. In common with other receptor tyrosine kinase family members, RYK is composed of three domains, an N-terminal, extracellular ligand-binding domain, a transmembrane spanning domain and a C-terminal intracellular domain.

However, in contrast to other receptor tyrosine kinases the C-terminal domain of RYK is devoid of detectable kinase s: RYK, D3S, JTK5, JTK5A, RYK1. Overexpression of ERK, an EPH family receptor protein tyrosine kinase, in various human tumors Article (PDF Available) in Cancer Research 54(14) August with Reads.

Activation of EphA receptor tyrosine kinase inhibits the Ras/MAPK pathway Article in Nature Cell Biology 3(5) June with 58 Reads How we measure 'reads'.

The fidelity of ERK MAP kinase signaling. The MAP kinase (MAPK) cascades convey signals in the form of phosphorylation events. Therefore, MAPKs form a complex with their cognate MAPKKs, substrates and phosphatases.

There are three major subgroups of Cited by:   Animated and descriptive video on Receptor tyrosine kinases RTKs #BiotechReview #ReceptorTyrosineKinases #CellSignaling.

Introduction Tyrosine kinases are important mediators of the signaling cascade, determining key roles in diverse biological processes like growth, differentiation, metabolism and apoptosis in response to external and internal stimuli. A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to a protein in a cell.

In mammals, these are ERKs (extracellular-signal-regulated kinases), JNKs (Jun amino-terminal kinases), and p38/SAPKs (stress-activated protein kinases). ERK family members possess a TEY motif in the activation segment and can be subdivided into two groups: the classic ERKs that consist mainly of a kinase domain (ERK1 and ERK2) and the larger.

This video is unavailable. Watch Queue Queue. Watch Queue Queue. kinase was the first protein kinase to be characterized biochemically and the mechanism of its regula-tion led to the discovery of cAMP-dependent protein kinase (protein kinase A, or PKA), which catalyzes the phosphorylation and activation of phosphorylase kinase.

This was the first protein kinase cascade or signaling module to be elucidated. Receptor tyrosine kinases (RTKs), a family of cell-surface receptors, which transduce signals to polypeptide and protein hormones, cytokines and growth factors are key regulators of critical cellular processes, such as proliferation and differentiation, cell survival and metabolism, cell migration and cell cycle control [,4].In the human genome, 58 RTKs have been identified, which fall into.

The receptor tyrosine kinases are not only cell surfaces transmembrane receptors, but are also enzymes having kinase activity. Cytoplasm portion contains a tyrosine kinase domain. The kinase domain has regulatory sequence both on the N and C terminal end The first non- receptor tyrosine kinases identified was the SRC.

Non-receptor tyrosine File Size: KB. The Receptor Tyrosine Kinase EphB2 Promotes Hepatic Fibrosis in Mice Patrice N. Mimche,1 Lauren M. Brady,1 Christian F. Bray,1 Choon M.

Lee,2 Manoj Thapa,3 Thayer P. King,1 Kendra Quicke,1 Courtney D. McDermott,1 Sylvie M. Mimche,2 Arash Grakoui,3 Edward T. Morgan,2 and Tracey J. Lamb1 Beyond the well-defined role of the Eph (erythropoietin-producing hepatocellular)Cited by:   Tyrosine kinase report 1.

TYROSINE KINASE by: Mary Jean D. Somcio 2. INTRODUCTION• Protein kinases are a group of enzymes that possess a catalytic subunit that transfers the gamma (terminal) phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function.Abstract.

Receptor tyrosine kinases (RTKs) and their cellular signaling pathways play important roles in normal development and homeostasis. Aberrations in their activation or signaling leads to many pathologies, especially cancers, motivating the development of a variety of drugs that block RTK signaling that have been successfully applied for the treatment of many cancers.